Aphorism 135

§ 135

The whole of the elements of disease a medicine is capable of producing can only be brought to anything like completeness by numerous observations on suitable persons of both sexes and of various constitutions. We can only be assured that a medicine has been thoroughly proved in regard to the morbid states it can produce – that is to say, in regard to its pure powers of altering the health of man – when subsequent experimenters can notice little of a novel character from its action, and almost always only the same symptoms as had been already observed by others.

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Organon of medicine