ยง 134
All external influences, and more especially medicines, possess the property of producing in the health of the living organism a particular kind of alteration peculiar to themselves; but all the symptoms peculiar to a medicine do not appear in one person, nor all at once, nor in the same experiment, but some occur in one person chiefly at one time, others again during a second or third trail; in another person some other symptoms appear, but in such a manner that probably some of the phenomena are observed in the fourth, eighth or tenth person which had already appeared in the second, sixth or ninth person, and so forth; moreover, they may not recur at the same hour.